El zinc podría favorecer el incremento de los niveles de CD4 en personas con VIH

Según un estudio estadounidense publicado en la edición del 15 de junio de , el uso de suplementos de zinc podría ayudar a disminuir la progresión de la infección por VIH en personas que no consiguen obtener una viremia indetectable a pesar de seguir una terapia antirretroviral(TARV).

El zinc es un micronutriente esencial y su déficit se asocia con la inmunosupresión, lo que favorece la progresión de las infecciones, sobre todo la producida por el VIH. La falta de este mineral altera el equilibrio existente entre dos tipos de linfocitos: los Th1 y los Th2. Ante el déficit de zinc, el equilibrio se decanta a favor de los linfocitos Th2, que facilitan la producción de correceptores como el CXCR4 o el LTB4, que posibilitan la entrada del VIH en las células.

Se calcula que más de la mitad de las personas con VIH presentan unos niveles de zinc inferiores a los recomendados, por lo que los autores del presente estudio decidieron examinar la administración prolongada de suplementos del mineral para compensar su déficit.

El ensayo, de distribución aleatoria y controlado con placebo, contó con la participación de 231 personas con VIH y bajos niveles plasmáticos de zinc (inferiores a 0,75 mg/L). Los voluntarios recibieron suplementos de este mineral (12mg de zinc elemental en mujeres y 15mg en hombres) ó placebo durante 18 meses. El objetivo principal del ensayo fue determinar las tasas de fracaso inmunitario, definido como presentar unos niveles de CD4 inferiores a 200 células/mm3 en cualquier momento del estudio.

La edad media de los participantes en el estudio fue de 43 años. El 77% de ellos eran de etnia negra y el 73%, hombres. Aunque el 62% de los pacientes recibían TARV, el 69% tenían una carga viral indetectable, lo que indica un mal control de la infección. Al entrar en el ensayo, el 34% de las personas tenían unos niveles de CD4 inferiores a 200 células/mm3, el 22%, entre 200 y 350 células/mm3 y el 44%, superiores a 350 células/mm3.

Tras ajustar los resultados en función de la edad, el sexo, la alimentación, la carga viral y el recuento de CD4 al inicio del estudio, la toma de suplementos de zinc durante 18 meses resultó en una reducción del 75% de la probabilidad de experimentar un fracaso inmunitario.

La administración del mineral también redujo la incidencia de diarrea en más de la mitad. Por otro lado, no se observó que la toma de suplementos de zinc redujera el riesgo de muerte, ya que 8 personas del grupo con placebo y 11 del grupo que recibió el mineral murieron durante el estudio. Los investigadores justificaron este dato aduciendo que el ensayo no estaba diseñado para esclarecer este aspecto.

La toma de zinc fue considerada segura, sin registrarse casos con efectos adversos graves. Los autores del estudio concluyeron que los resultados podrían favorecer recomendaciones relativas a la toma de suplementos de zinc en personas con VIH, especialmente aquéllas en las que el déficit del mineral es importante, como los usuarios de drogas, niños, hombres que practican sexo con hombres, personas de países con recursos limitados o en las que la TARV no permita un control virológico adecuado.

Fuente:  gTt-VIH

Referencia: Baum MK, Lai S, Sales S, Page JB, Campa A.  (2010). Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis.  Vol  50, Num 12, pp. 1.653-1.660.


58 Replies to “El zinc podría favorecer el incremento de los niveles de CD4 en personas con VIH”

  1. asmr https://0mniartist.tumblr.com

    Howdy just wanted to give you a brief heads up and let
    you know a few of the pictures aren’t loading correctly.
    I’m not sure why but I think its a linking issue.

    I’ve tried it in two different web browsers and
    both show the same results. 0mniartist asmr

  2. 0mniartist

    A person essentially assist to make severely articles I’d state.

    That is the first time I frequented your website page and to this point?
    I amazed with the analysis you made to make this particular
    put up incredible. Wonderful activity! 0mniartist asmr

  3. gamefly their

    Thank you, I have just been looking for info approximately this subject for ages and yours is the greatest I’ve came upon till now.
    But, what concerning the bottom line? Are you positive about the
    supply?

  4. asmr on

    Thanks for your personal marvelous posting!
    I certainly enjoyed reading it, you happen to be a great author.

    I will be sure to bookmark your blog and will often come back later on.
    I want to encourage one to continue your great job, have a nice day!

  5. asmr was

    you are actually a excellent webmaster. The website loading speed is amazing.

    It seems that you are doing any distinctive trick. Also, The contents are masterwork.
    you have done a excellent activity on this matter!

  6. gamefly with

    Hi I am so excited I found your web site, I really
    found you by mistake, while I was browsing on Bing for something
    else, Anyhow I am here now and would just like to say thank you for a marvelous post and a all
    round entertaining blog (I also love the theme/design), I don’t have time to read through it all at
    the moment but I have book-marked it and also added your RSS feeds,
    so when I have time I will be back to read a great deal more,
    Please do keep up the great jo.

  7. asmr off

    Hello there, just became alert to your blog through Google, and found that
    it’s really informative. I am going to watch out for brussels.
    I’ll appreciate if you continue this in future.

    Lots of people will be benefited from your writing. Cheers!

  8. bitly.com

    Thanks for the good writeup. It if truth be told was once a entertainment
    account it. Look complicated to more introduced agreeable from
    you! By the way, how can we be in contact?

  9. asmr what

    Hi there to all, how is the whole thing, I think every one is getting more from this website, and your views
    are nice in favor of new viewers.

  10. http://bit.ly/

    scoliosis
    Valuable information. Lucky me I found your website unintentionally, and I’m shocked why this
    accident didn’t came about earlier! I bookmarked it.
    scoliosis

  11. bit.ly

    scoliosis
    This is the perfect web site for anyone who really wants to understand this topic.
    You know a whole lot its almost tough to argue with you (not that I really would want to…HaHa).
    You certainly put a brand new spin on a topic that’s been discussed for many years.

    Excellent stuff, just wonderful! scoliosis

  12. j.mp

    scoliosis
    I am genuinely pleased to read this webpage posts which
    consists of lots of useful facts, thanks
    for providing these data. scoliosis

  13. https://6869milesoflove.tumblr.com/

    free dating sites
    Fantastic blog! Do you have any suggestions for aspiring writers?
    I’m hoping to start my own site soon but I’m a little lost on everything.
    Would you propose starting with a free platform like WordPress or go for a paid option? There are
    so many options out there that I’m totally confused ..
    Any tips? Cheers! dating sites

  14. asmr our

    This is really attention-grabbing, You’re an excessively skilled blogger.
    I have joined your feed and sit up for searching for more of your magnificent post.
    Additionally, I’ve shared your website in my social networks

  15. dating sites for

    Great work! This is the type of info that should be shared across the internet.
    Disgrace on Google for not positioning this submit upper!
    Come on over and discuss with my site . Thank you =)

  16. our scoliosis

    Oh my goodness! Incredible article dude! Thank you so much,
    However I am encountering difficulties with your RSS. I don’t understand why I can’t
    subscribe to it. Is there anybody having identical RSS problems?
    Anybody who knows the solution will you kindly respond?
    Thanks!!

  17. dating sites it

    Good day I am so grateful I found your website, I really found you by mistake, while I was researching on Digg for something else, Anyways
    I am here now and would just like to say thanks for
    a fantastic post and a all round entertaining blog (I also love the theme/design), I don’t have time
    to read it all at the moment but I have saved it
    and also added your RSS feeds, so when I have time I will
    be back to read much more, Please do keep up the great work.

  18. in dating sites

    I am curious to find out what blog system you happen to
    be working with? I’m experiencing some small security problems with my latest website and I would
    like to find something more risk-free. Do you have any suggestions?

  19. tinyurl.com

    Undeniably believe that which you stated. Your favorite reason seemed to
    be on the web the simplest thing to be aware of. I say to you,
    I definitely get irked while people think about worries that they plainly do not know about.
    You managed to hit the nail upon the top and also defined out the whole thing without having side effect , people could take a
    signal. Will probably be back to get more. Thanks

  20. tinyurl.com

    Undeniably believe that which you stated. Your favorite justification seemed
    to be on the internet the easiest thing to be aware of.
    I say to you, I certainly get irked while people consider
    worries that they plainly do not know about. You managed to hit the nail upon the top as
    well as defined out the whole thing without having side effect , people could take a signal.
    Will probably be back to get more. Thanks

  21. tinyurl.com

    My brother suggested I might like this blog. He was entirely right.
    This post actually made my day. You cann’t imagine just how much time I had spent for this information! Thanks!

  22. tinyurl.com

    What i do not understood is if truth be told how you
    are no longer actually much more well-favored than you may be
    right now. You are very intelligent. You understand thus significantly with
    regards to this subject, made me in my view consider it from numerous numerous angles.
    Its like women and men don’t seem to be fascinated except it is one thing to accomplish with Woman gaga!

    Your individual stuffs nice. At all times deal
    with it up!

  23. tinyurl.com

    Howdy! This is kind of off topic but I need some guidance from an established blog.
    Is it very difficult to set up your own blog? I’m not very techincal but
    I can figure things out pretty quick. I’m thinking about
    setting up my own but I’m not sure where to start. Do you have any ideas or suggestions?
    With thanks

  24. bitly.com

    Hmm it looks like your site ate my first comment (it was extremely long) so I guess
    I’ll just sum it up what I had written and say, I’m thoroughly enjoying your blog.
    I too am an aspiring blog blogger but I’m still new to the whole
    thing. Do you have any tips for rookie blog writers?
    I’d really appreciate it.

  25. gamefly of

    I don’t even understand how I ended up right here, but I assumed
    this publish was once great. I do not know who you’re but definitely
    you’re going to a famous blogger should you are not already.
    Cheers!

  26. it ps4 games

    This is very interesting, You’re a very skilled blogger.

    I’ve joined your feed and look forward to seeking more of your fantastic post.

    Also, I’ve shared your website in my social networks!

  27. ps4 games off

    Hi there I am so grateful I found your site, I really found you by accident, while I was
    searching on Yahoo for something else, Anyhow I am here now and
    would just like to say thank you for a marvelous post and a all
    round entertaining blog (I also love the theme/design), I don’t have time to go through it
    all at the moment but I have saved it and also added your RSS
    feeds, so when I have time I will be back to read a lot
    more, Please do keep up the superb work.

  28. t.co

    Greate pieces. Keep writing such kind of info on your blog.
    Im really impressed by it.
    Hey there, You have performed a fantastic job. I’ll certainly
    digg it and personally recommend to my friends. I am confident they will be benefited from this website.

  29. Kina

    Thanks for finally writing about > El zinc podría favorecer el incremento
    de los niveles de CD4 en personas con VIH – Noticias Equipo Sida-Aids.org < Loved it!

  30. for quest bars

    Wonderful beat ! I wish to apprentice while you amend your web site,
    how can i subscribe for a blog web site? The account aided me a acceptable
    deal. I had been tiny bit acquainted of this your broadcast provided bright clear concept

  31. http://bit.ly/38vuS56

    We are a group of volunteers and starting a new scheme in our community.

    Your web site offered us with valuable information to work on. You have done
    a formidable job and our entire community will be grateful to you.

  32. bit.ly

    My brother recommended I may like this web site.
    He was totally right. This submit actually made my day.
    You cann’t consider simply how so much time I had spent for this info!
    Thanks!

  33. http://j.mp

    I am really loving the theme/design of your website.
    Do you ever run into any browser compatibility
    problems? A number of my blog visitors have complained about my blog not working correctly in Explorer but looks great in Firefox.

    Do you have any solutions to help fix this issue?

  34. in quest bars

    First off I want to say great blog! I had a quick question which I’d like to ask if you
    do not mind. I was curious to know how you center yourself
    and clear your thoughts before writing. I have had trouble clearing my thoughts in getting my ideas out.
    I do take pleasure in writing but it just seems like the first 10 to 15 minutes are lost simply just trying
    to figure out how to begin. Any ideas or tips?
    Many thanks! quest bars http://bit.ly/3jZgEA2 quest bars

  35. tinyurl.com

    I loved as much as you will receive carried
    out right here. The sketch is attractive, your authored
    material stylish. nonetheless, you command get got an impatience
    over that you wish be delivering the following.
    unwell unquestionably come further formerly again as exactly the same nearly a lot
    often inside case you shield this hike. ps4 https://bitly.com/3nkdKIi ps4 games

Deja un comentario

Tu dirección de correo electrónico no será publicada.