Un estudio en el que han participado más de 60 personas infectadas por el VIH ha permitido identificar seis genes implicados en la progresión rápida de la infección, gracias a los cuales es posible prever cómo evolucionará el virus en cada paciente.
El trabajo, publicado en el último número de la revista Journal of Clinical Investigation, revela que al menos 8 de cada 100 personas infectadas por el VIH responden a un modelo de progresión rápida; es decir, que la infección evoluciona muy rápidamente en su organismo y, en menos de tres años, su sistema inmunitario se ve muy deteriorado. El número inesperadamente elevado de pacientes con progresión rápida subraya la necesidad de reforzar el diagnóstico precoz para evitar casos fulminantes de SIDA y reforzar la prevención.
Los científicos apuntan que, dado que estos genes están relacionados con la activación del sistema inmunitario, la vacuna por el VIH se podría diseñar de tal forma que fuera capaz de manipularlos para estimular una respuesta inmunitaria adecuada. El estudio ha sido liderado por investigadores del Instituto de Investigación del Sida IrsiCaixa y el Departamento de Salud de la Generalitat de Catalunya, y ha contado, además, con la colaboración del Hospital Clínico de Barcelona y del Banc de Sang i Teixits, además de otras instituciones de ámbito internacional.
Según el investigador de IrsiCaixa responsable del estudio, Javier Martínez-Picado, que es asimismo profesor de investigación de ICREA, “la identificación de este grupo de genes ha sido posible gracias a que hemos conseguido reclutar la primera y más extensa cohorte de seguimiento de pacientes en los que la infección evoluciona de forma muy rápida, y hemos podido identificar además el porcentaje de estos tipos de pacientes, que es sorprendentemente elevado. Conocer estos genes resulta esencial para poder prever si el sistema inmunitario de los pacientes va a verse deteriorado rápidamente y recomendar así los tratamientos con mayores garantías de éxito”.
Hasta ahora, los casos de progresión rápida eran anecdóticos en la literatura científica, dada la complejidad para determinar la fecha de la infección y el breve período de tiempo disponible para identificar a estos pacientes, entre su diagnóstico y el inicio del tratamiento antirretroviral.
El estudio se ha llevado a cabo con una cohorte desarrollada conjuntamente con el Hospital Universitario de Lausanne, en Suiza, a partir del screening de miles de pacientes, de los cuales más de 100 habían desarrollado una progresión rápida de la infección. Para ser incluidos en la cohorte, era necesario que los pacientes reunieran dos condiciones básicas: que se hubieran sometido a la prueba del VIH previamente al contagio, para poder conocer la fecha aproximada en la que se infectaron –es decir, que entre la última prueba del VIH con resultado negativo y la detección de la infección hubiera transcurrido menos de un año– y que en menos de tres años presentaran un nivel de linfocitos T4 en sangre inferior a 350 por milímetro cúbico (que es el criterio médico para empezar a tratar la enfermedad).
A 66 de estos pacientes, la mitad de ellos de Barcelona y la otra mitad de Suiza, se les analizaron medio millón de posiciones de su ADN, así como de combinaciones de los genes conocidos como HLA que, en estudios anteriores, ya se habían asociado al ritmo de progresión de la infección por VIH. Los resultados confirmaron esta asociación en los pacientes con progresión rápida.
El proyecto HIVACAT de investigación y desarrollo de una vacuna contra el VIH está integrado por Los codirectores del proyecto HIVACAT son el Dr. Bonaventura Clotet, de IrsiCaixa, y el Dr. Josep Maria Gatell, del Hospital Clínic. Ambos centros desarrollan la investigación conjuntamente con más de cinco mil enfermos, quienes se benefician de la rápida incorporación de los nuevos tratamientos y de las innovaciones adquiridas en el ámbito internacional. HIVACAT cuenta con un equipo integrado por más de sesenta científicos formados en centros investigadores de prestigio internacional, como la Universidad de Harvard, el Instituto Pasteur de París o el Royal Free Hospital de Londres.
Great article. 0mniartist asmr
Do you have a spam problem on this blog; I also am a
blogger, and I was curious about your situation; many of us have created some nice methods and we are looking to trade strategies with other folks, why not
shoot me an e-mail if interested. asmr 0mniartist
First off I would like to say superb blog! I had a quick question that I’d like to ask if you don’t mind.
I was curious to know how you center yourself and clear your head prior to writing.
I have had a hard time clearing my thoughts in getting my thoughts out.
I do take pleasure in writing but it just seems like the first 10
to 15 minutes are wasted just trying to figure out how to begin. Any
suggestions or hints? Thank you! 0mniartist asmr
I get pleasure from, lead to I found just what I used to be taking a look for.
You’ve ended my four day long hunt! God Bless you man. Have a nice day.
Bye 0mniartist asmr
I am actually thankful to the holder of this web site who has shared
this impressive post at at this time. asmr 0mniartist
Very nice article, totally what I was looking for.
If you wish for to improve your knowledge simply keep
visiting this web site and be updated with the latest information posted here.
Very nice post. I simply stumbled upon your blog and wished to
mention that I’ve really enjoyed surfing around your blog posts.
After all I’ll be subscribing to your feed and I am hoping you write once more very soon!
Your mode of describing everything in this article is actually fastidious, every one
be capable of easily be aware of it, Thanks a lot.
Do you have any video of that? I’d care to find out more details.
This design is wicked! You most certainly know how to keep a reader amused.
Between your wit and your videos, I was
almost moved to start my own blog (well, almost…HaHa!) Excellent job.
I really enjoyed what you had to say, and more than that, how you presented it.
Too cool!
Pretty great post. I simply stumbled upon your blog and wished to mention that I’ve truly enjoyed surfing around your weblog
posts. In any case I’ll be subscribing in your rss feed and I am hoping you write once more very soon!
What a material of un-ambiguity and preserveness of precious familiarity
about unpredicted emotions.
Inspiring quest there. What occurred after?
Thanks!
scoliosis
Just want to say your article is as surprising.
The clearness in your post is just excellent and i could assume you’re an expert on this subject.
Well with your permission let me to grab your feed to keep updated with
forthcoming post. Thanks a million and please carry on the enjoyable work.
scoliosis
scoliosis
Currently it seems like Movable Type is the top blogging platform available right now.
(from what I’ve read) Is that what you are using on your blog?
scoliosis
scoliosis
Hi! Do you know if they make any plugins to safeguard against hackers?
I’m kinda paranoid about losing everything
I’ve worked hard on. Any recommendations? scoliosis
free dating sites
It is the best time to make a few plans for the longer term and it is time to be happy.
I have learn this put up and if I may I desire to counsel
you few attention-grabbing things or tips. Maybe you can write subsequent articles regarding this article.
I desire to read more issues approximately it! dating sites
https://785days.tumblr.com/
free dating sites
I’m extremely impressed with your writing abilities and also with the format on your weblog.
Is that this a paid subject matter or did you modify it
yourself? Either way stay up the nice high quality writing, it’s uncommon to peer a great weblog
like this one nowadays.. free dating sites
It’s going to be ending of mine day, except before finish I
am reading this fantastic paragraph to increase my experience.
Appreciate this post. Will try it out.
My partner and I stumbled over here different website and thought I may as well check things out.
I like what I see so i am just following you. Look forward to looking into your web page repeatedly.
Pretty section of content. I just stumbled upon your blog and
in accession capital to assert that I get
actually enjoyed account your blog posts. Anyway I will be subscribing to your
feeds and even I achievement you access consistently
rapidly.
Admiring the dedication you put into your blog and in depth information you offer.
It’s good to come across a blog every once in a while that isn’t the same outdated rehashed material.
Great read! I’ve saved your site and I’m including your
RSS feeds to my Google account.
Wow, awesome weblog format! How lengthy have you been running a blog for?
you made running a blog look easy. The overall look of your web site
is wonderful, as neatly as the content material!
Thank you, I’ve recently been looking for information approximately
this subject for ages and yours is the greatest I’ve found out till now.
However, what about the conclusion? Are you sure in regards to the source?
Hi there, just wanted to tell you, I enjoyed this
article. It was inspiring. Keep on posting!
Post writing is also a fun, if you be familiar with after that you can write otherwise it is
difficult to write.
Excellent beat ! I wish to apprentice even as you amend your website, how could
i subscribe for a blog website? The account helped
me a appropriate deal. I have been tiny bit
familiar of this your broadcast offered shiny transparent idea
Hello just wanted to give you a brief heads up and let you know a few of the images aren’t loading properly.
I’m not sure why but I think its a linking issue. I’ve
tried it in two different internet browsers and both show
the same outcome.
Hello! Someone in my Myspace group shared this site with
us so I came to take a look. I’m definitely loving the information. I’m book-marking and will
be tweeting this to my followers! Exceptional blog and brilliant design and style.
Hi, i think that i saw you visited my web site so
i came to “return the favor”.I am trying to find things to improve my web
site!I suppose its ok to use some of your ideas!!
Good day! I just would like to offer you a big thumbs up for your great information you’ve got here
on this post. I’ll be returning to your site for more soon.
Hi there colleagues, how is all, and what you desire to say concerning this post, in my view its in fact amazing for me.
Great blog! Is your theme custom made or did you download
it from somewhere? A design like yours with a few simple
adjustements would really make my blog shine. Please let me know where you got your theme.
Thank you
Incredible story there. What occurred after? Good luck!
Very good info. Lucky me I discovered your website by accident (stumbleupon).
I’ve saved as a favorite for later!
I like the valuable information you provide in your articles.
I’ll bookmark your blog and check once more here frequently.
I’m reasonably certain I’ll be informed a lot of
new stuff proper right here! Best of luck for the next!
Have you ever considered creating an ebook or guest authoring on other websites?
I have a blog based upon on the same topics you discuss and
would love to have you share some stories/information. I know
my subscribers would appreciate your work. If you are even remotely interested, feel free to send me an e-mail.
Hi there everyone, it’s my first visit at this website,
and piece of writing is actually fruitful in favor of me, keep
up posting such content.
With havin so much content do you ever run into any issues of plagorism or copyright violation? My site
has a lot of unique content I’ve either authored myself or outsourced but it looks like a lot of it is popping it up all over the internet without my authorization. Do you know any ways
to help protect against content from being ripped off?
I’d really appreciate it.
Howdy! I just want to offer you a huge thumbs up for
your great info you’ve got here on this post. I am returning to
your site for more soon.
Nice response in return of this question with real arguments and explaining everything regarding that.
This piece of writing is in fact a pleasant one it assists new web viewers, who are wishing
in favor of blogging.
Thanks very nice blog!
Does your site have a contact page? I’m having trouble locating it but, I’d like
to send you an email. I’ve got some ideas for your blog you
might be interested in hearing. Either way, great blog and I look forward to seeing it improve over time.
Wow, awesome blog layout! How long have you been blogging for?
you make blogging look easy. The overall look of your web site is fantastic,
let alone the content! asmr https://app.gumroad.com/asmr2021/p/best-asmr-online asmr
Oh my goodness! Impressive article dude! Many thanks, However I am experiencing troubles with
your RSS. I don’t know why I can’t subscribe to it. Is there anybody else having the same
RSS problems? Anybody who knows the answer can you kindly respond?
Thanx!! quest bars http://bit.ly/3jZgEA2 quest bars
Heya! I just wanted to ask if you ever have any problems with hackers?
My last blog (wordpress) was hacked and I ended up losing months of hard work due to no backup.
Do you have any methods to prevent hackers?
It is perfect time to make a few plans for the long run and it is
time to be happy. I have read this submit and if I may just I wish to counsel you few interesting
issues or tips. Maybe you could write subsequent articles referring to this article.
I want to learn more things approximately it!